CDK6 anticorps (AA 102-326) (Biotin)

N° du produit ABIN7148899

Cet anticorps anti-CDK6 est un anticorps Lapin Polyclonal détectant CDK6 dans ELISA. Adapté pour Humain.

Aperçu rapide pour CDK6 anticorps (AA 102-326) (Biotin) (ABIN7148899)

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK6 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-CDK6 anticorps (Biotin)

Épitope: AA 102-326

Fonction: CDK6 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Cyclin-dependent kinase 6 protein (102-326AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CDK6

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Autre désignation: CDK6

Sujet:

Background: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

Aliases: CDK 6 antibody, CDK6 antibody, CDK6_HUMAN antibody, Cell division protein kinase 6 antibody, Crk 2 antibody, Crk2 antibody, Cyclin dependent kinase 6 antibody, Cyclin-dependent kinase 6 antibody, MCPH12 antibody, MGC59692 antibody, p40 antibody, PLSTIRE antibody, Serine/threonine protein kinase PLSTIRE antibody, Serine/threonine-protein kinase PLSTIRE antibody, STQTL11 antibody

UniProt: Q00534

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases