AMFR anticorps (AA 485-643) (FITC)

N° du produit ABIN7150980

L’anticorps Lapin Polyclonal anti-AMFR a été validé pour . Il convient pour détecter AMFR dans des échantillons de Humain.

Aperçu rapide pour AMFR anticorps (AA 485-643) (FITC) (ABIN7150980)

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMFR est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-AMFR anticorps (FITC)

Épitope: AA 485-643

Fonction: AMFR Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AMFR

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Autre désignation: AMFR

Sujet:

Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Aliases: AMF receptor antibody, AMF receptor isoform 1 antibody, AMF receptor isoform 2 antibody, AMFR antibody, AMFR2_HUMAN antibody, Autocrine motility factor receptor antibody, Autocrine motility factor receptor precursor, isoform 1 antibody, Autocrine motility factor receptor precursor, isoform 2 antibody, E3 ubiquitin-protein ligase AMFR antibody, gp78 antibody, isoform 2 antibody, RING finger protein 45 antibody, RNF 45 antibody, RNF45 antibody

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling