Ephrin A1 anticorps (AA 19-182)

N° du produit ABIN7151874

L’anticorps Lapin Polyclonal anti-Ephrin A1 a été validé pour ELISA et IHC. Il convient pour détecter Ephrin A1 dans des échantillons de Humain.

Aperçu rapide pour Ephrin A1 anticorps (AA 19-182) (ABIN7151874)

Antigène: Ephrin A1 (EFNA1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-Ephrin A1 anticorps

Épitope: AA 19-182

Fonction: EFNA1 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ephrin-A1 protein (19-182AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Ephrin A1

Antigène: Ephrin A1 (EFNA1)

Autre désignation: EFNA1

Sujet:

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Aliases: B61 antibody, ECKLG antibody, EFL 1 antibody, EFL1 antibody, EFNA 1 antibody, Efna1 antibody, EFNA1_HUMAN antibody, EPH related receptor tyrosine kinase ligand 1 antibody, EPH-related receptor tyrosine kinase ligand 1 antibody, Ephrin-A1 antibody, Ephrin-A1, secreted form antibody, EphrinA1 antibody, EPLG 1 antibody, EPLG1 antibody, Immediate early response protein B61 antibody, LERK 1 antibody, LERK-1 antibody, LERK1 antibody, Ligand of eph related kinase 1 antibody, OTTHUMP00000033242 antibody, OTTHUMP00000033271 antibody, secreted form antibody, TNF alpha-induced protein 4 antibody, TNFAIP 4 antibody, TNFAIP4 antibody, Tumor necrosis factor alpha induced protein 4 antibody, Tumor necrosis factor alpha-induced protein 4 antibody

UniProt: P20827

Pathways: Signalisation RTK