FGFR2 anticorps (AA 577-821)

N° du produit ABIN7152833

Cet anticorps Lapin Polyclonal détecte spécifiquement FGFR2 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour FGFR2 anticorps (AA 577-821) (ABIN7152833)

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-FGFR2 anticorps

Épitope: AA 577-821

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Fibroblast growth factor receptor 2 protein (577-821AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FGFR2

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Autre désignation: FGFR2

Sujet:

Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Aliases: bacteria-expressed kinase antibody, BBDS antibody, BEK antibody, BEK fibroblast growth factor receptor antibody, BFR1 antibody, CD332 antibody, CD332 antigen antibody, CEK3 antibody, CFD1 antibody, Craniofacial dysostosis 1 antibody, ECT1 antibody, FGF receptor antibody, FGFR 2 antibody, FGFR-2 antibody, Fgfr2 antibody, FGFR2_HUMAN antibody, Fibroblast growth factor receptor 2 antibody, Hydroxyaryl protein kinase antibody, Jackson Weiss syndrome antibody, JWS antibody, K SAM antibody, K-sam antibody, Keratinocyte growth factor receptor 2 antibody, Keratinocyte growth factor receptor antibody, KGFR antibody, KSAM antibody, protein tyrosine kinase, receptor like 14 antibody, soluble FGFR4 variant 4 antibody, TK14 antibody, TK25 antibody

UniProt: P21802

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding