FZD4 anticorps (AA 37-222) (FITC)

N° du produit ABIN7153187

Cet anticorps Lapin Polyclonal détecte spécifiquement FZD4 dans . Il présente une réactivité envers Humain.

Aperçu rapide pour FZD4 anticorps (AA 37-222) (FITC) (ABIN7153187)

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD4 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-FZD4 anticorps (FITC)

Épitope: AA 37-222

Fonction: FZD4 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Frizzled-4 protein (37-222AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FZD4

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Autre désignation: FZD4

Sujet:

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Aliases: CD 344 antibody, CD 344 antigen antibody, CD344 antibody, CD344 antigen antibody, EVR1 antibody, FEVR antibody, Frizzled (Drosophila) homolog 4 antibody, Frizzled 4 antibody, Frizzled family receptor 4 antibody, Frizzled homolog 4 (Drosophila) antibody, Frizzled-4 antibody, Fz 4 antibody, Fz-4 antibody, Fz4 antibody, FZD4 antibody, FZD4_HUMAN antibody, FZD4S antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, MGC34390 antibody, WNT receptor frizzled 4 antibody

UniProt: Q9ULV1

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound