Integrin beta 2 anticorps (AA 37-201)

N° du produit ABIN7156481

Cet anticorps Lapin Polyclonal détecte spécifiquement Integrin beta 2 dans IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour Integrin beta 2 anticorps (AA 37-201) (ABIN7156481)

Antigène: Integrin beta 2 (ITGB2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Integrin beta 2 anticorps

Épitope: AA 37-201

Fonction: ITGB2 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Integrin beta-2 protein (37-201AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Integrin beta 2

Antigène: Integrin beta 2 (ITGB2)

Autre désignation: ITGB2

Sujet:

Background: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in assosiation with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Aliases: 95 subunit beta antibody, Beta 2 (antigen CD18 (p95) antibody, CD 18 antibody, CD18 antibody, Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) antibody, Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta antibody, Cell surface adhesion glycoproteins LFA-1/CR3/p150 antibody, Complement component 3 receptor 3 and 4 subunit antibody, Complement receptor C3 beta subunit antibody, Complement receptor C3 subunit beta antibody, Integrin beta 2 antibody, Integrin beta chain beta 2 antibody, Integrin beta-2 (ITGB2) antibody, Integrin beta-2 antibody, Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) antibody, ITB2_HUMAN antibody, ITGB2 antibody, LAD antibody, LCAMB antibody, Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C antibody, Leukocyte cell adhesion molecule CD18 antibody, LFA 1 antibody, LFA1 antibody, Lymphocyte function associated antigen 1 (LFA1) antibody, Lymphocyte function associated antigen 1 antibody, MAC 1 antibody, MAC1 antibody, Macrophage antigen 1 (mac1) beta antibody, MF17 antibody, MFI7 antibody, OTTHUMP00000115278 antibody, OTTHUMP00000115279 antibody, OTTHUMP00000115280 antibody, OTTHUMP00000115281 antibody, OTTHUMP00000115282 antibody

UniProt: P05107

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation