PRKRA anticorps (AA 1-313)

N° du produit ABIN7156699

Détail du produit anti-PRKRA anticorps

Antigène: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Épitope: AA 1-313

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKRA est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRKRA

Antigène: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Autre désignation: PRKRA (PRKRA Produits)

Synonymes: anticorps PRKRA, anticorps AV120107, anticorps PRK, anticorps Pact, anticorps RAX, anticorps lear, anticorps DYT16, anticorps PACT, anticorps im:7151758, anticorps zgc:162619, anticorps dyt16, anticorps pact, anticorps prkra-a, anticorps prkra-b, anticorps rax, anticorps rbpa, anticorps protein activator of interferon induced protein kinase EIF2AK2, anticorps protein kinase, interferon inducible double stranded RNA dependent activator, anticorps protein kinase, interferon-inducible double stranded RNA dependent activator, anticorps protein activator of interferon induced protein kinase EIF2AK2 L homeolog, anticorps PRKRA, anticorps Prkra, anticorps prkra, anticorps prkra.L

Sujet:

Background: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \\\'Lys-386\\\' at \\\'Ser-392\\\' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Aliases: DYT16 antibody, HSD14 antibody, Interferon inducible double stranded RNA dependent protein kinase activator A antibody, interferon-inducible double stranded RNA-dependent activator antibody, Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody, PACT antibody, PKR associated protein X antibody, PKR associating protein X antibody, PKR-associated protein X antibody, PKR-associating protein X antibody, PRKRA antibody, PRKRA_HUMAN antibody, Protein activator of the interferon induced protein kinase antibody, Protein activator of the interferon-induced protein kinase antibody, Protein kinase antibody, Protein kinase interferon inducible double stranded RNA dependent activator antibody, RAX antibody

UniProt: O75569

Pathways: Regulatory RNA Pathways