AIM2 anticorps (AA 81-326)

N° du produit ABIN7156703

Cet anticorps Lapin Polyclonal détecte spécifiquement AIM2 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour AIM2 anticorps (AA 81-326) (ABIN7156703)

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-AIM2 anticorps

Épitope: AA 81-326

Fonction: AIM2 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AIM2

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Autre désignation: AIM2

Sujet:

Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Aliases: Absent in melanoma 2 antibody, AIM 2 antibody, Aim2 antibody, AIM2_HUMAN antibody, Interferon-inducible protein AIM2 antibody, OTTHUMP00000035296 antibody, PYHIN4 antibody

UniProt: O14862

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome