JMY anticorps (AA 708-848)

N° du produit ABIN7157162

Détail du produit anti-JMY anticorps

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Épitope: AA 708-848

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMY est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Junction-mediating and -regulatory protein (708-848AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur JMY

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Autre désignation: JMY (JMY Produits)

Synonymes: anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy

Sujet:

Background: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

Aliases: FLJ37870 antibody, Jmy antibody, JMY protein antibody, JMY_HUMAN antibody, junction mediating and regulatory protein antibody, Junction mediating and regulatory protein p53 cofactor antibody, Junction-mediating and -regulatory protein antibody, MGC163496 antibody, OTTHUMP00000161976 antibody, WAS protein homology region 2 domain containing 1-like 3 antibody, WHDC1L3 antibody

UniProt: Q8N9B5

Pathways: Regulation of Actin Filament Polymerization