PIK3R1 anticorps (pTyr467) (Biotin)

N° du produit ABIN711538

Cet anticorps Lapin Polyclonal détecte spécifiquement PIK3R1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Porc.

Aperçu rapide pour PIK3R1 anticorps (pTyr467) (Biotin) (ABIN711538)

Antigène: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Reactivité: Humain, Souris, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3R1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PIK3R1 anticorps (Biotin)

Épitope: pTyr467

Réactivité croisée: Humain, Souris, Porc

Homologie: Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PIK3R1 around the phosphorylation site of Tyr467 [RL(p-Y)EE]

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PIK3R1

Antigène: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Autre désignation: PIK3R1

Sujet:

Synonyms: PIK3R1phospho Y467, GRB1, p50 alpha, p55 alpha, p85 alpha, p85, Phosphatidylinositol 3 kinase associated p85 alpha, Phosphatidylinositol 3 kinase regulatory 1, Phosphatidylinositol 3 kinase regulatory alpha subunit, Phosphoinositide 3 kinase regulatory subunit polypeptide 1 p85 alpha, PI3 kinase p85 alpha subunit, PI3 kinase p85 subunit alpha, PI3K , PIK3R1, PtdIns 3 kinase p85 alpha.

Background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

ID gène: 5295

Pathways: TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, L'effet Warburg