MDC1 anticorps (AA 1892-2082) (Biotin)

N° du produit ABIN7159097

Cet anticorps Lapin Polyclonal détecte spécifiquement MDC1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour MDC1 anticorps (AA 1892-2082) (Biotin) (ABIN7159097)

Antigène: MDC1 (Mdc1 (MDC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDC1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-MDC1 anticorps (Biotin)

Épitope: AA 1892-2082

Fonction: MDC1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MDC1

Antigène: MDC1 (Mdc1 (MDC1))

Autre désignation: MDC1

Sujet:

Background: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by \'Ser-139\' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Aliases: Homologue to Drosophila photoreceptor protein calphotin antibody, MDC 1 antibody, Mdc1 antibody, MDC1_HUMAN antibody, Mediation of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint protein 1 antibody, NFBD 1 antibody, NFBD1 antibody, Nuclear factor with BRCT domains 1 antibody, Nuclear Factor with BRCT Domains Protein 1 antibody

UniProt: Q14676