MAPK10 anticorps (AA 133-316) (Biotin)

N° du produit ABIN7159977

L’anticorps Lapin Polyclonal anti-MAPK10 a été validé pour ELISA. Il convient pour détecter MAPK10 dans des échantillons de Humain.

Aperçu rapide pour MAPK10 anticorps (AA 133-316) (Biotin) (ABIN7159977)

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPK10 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-MAPK10 anticorps (Biotin)

Épitope: AA 133-316

Fonction: MAPK10 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Mitogen-activated protein kinase 10 protein (133-316AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAPK10

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Autre désignation: MAPK10

Sujet:

Background: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Aliases: c Jun kinase 3 antibody, c-Jun N-terminal kinase 3 antibody, cJun N terminal kinase 3 antibody, FLJ12099 antibody, FLJ33785 antibody, JNK3 alpha protein kinase antibody, JNK3 antibody, JNK3A antibody, MAP kinase 10 antibody, MAP kinase antibody, MAP kinase p49 3F12 antibody, MAPK 10 antibody, Mapk10 antibody, MGC50974 antibody, mitogen activated protein kinase 10 antibody, Mitogen-activated protein kinase 10 antibody, MK10_HUMAN antibody, p493F12 antibody, p54bSAPK antibody, PRKM10 antibody, protein kinase mitogen activated 10 antibody, SAPK1b antibody, Stress activated protein kinase 1b antibody, stress activated protein kinase beta antibody, Stress activated protein kinase JNK3 antibody, Stress-activated protein kinase JNK3 antibody

UniProt: P53779

Pathways: Signalisation MAPK, Signalisation WNT, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades