NR1D2 anticorps (AA 14-318) (HRP)

N° du produit ABIN7161739

Détail du produit anti-NR1D2 anticorps (HRP)

Antigène: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Épitope: AA 14-318

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1D2 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human NR1D2 protein (14-318AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NR1D2

Antigène: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Autre désignation: NR1D2 (NR1D2 Produits)

Synonymes: anticorps BD73, anticorps EAR-1R, anticorps RVR, anticorps HZF-2, anticorps Rev-erb, anticorps REV-ERBB, anticorps NR1D2, anticorps rvr, anticorps bd73, anticorps hzf2, anticorps ear-1r, anticorps hs.37288, anticorps NR1D2-A, anticorps Reverbbeta-A, anticorps reverbb1, anticorps reverbb, anticorps reverbb2, anticorps zgc:92019, anticorps nuclear receptor subfamily 1 group D member 2, anticorps nuclear receptor subfamily 1, group D, member 2, anticorps nuclear receptor subfamily 1, group D, member 2a, anticorps nuclear receptor subfamily 1, group D, member 2b, anticorps NR1D2, anticorps Nr1d2, anticorps nr1d2, anticorps nr1d2a, anticorps nr1d2b

Sujet:

Background: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5\\\'-[A/G]GGTCA-3\\\' preceded by an A/T-rich 5\\\' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle.

Aliases: Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R), NR1D2

UniProt: Q6NSM0

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway