SERPINA5 anticorps (AA 157-367)

N° du produit ABIN7163528

Détail du produit anti-SERPINA5 anticorps

Antigène: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Épitope: AA 157-367

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SERPINA5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Plasma serine protease inhibitor protein (157-367AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SERPINA5

Antigène: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Autre désignation: SERPINA5 (SERPINA5 Produits)

Synonymes: anticorps 4933415L04, anticorps PAI-3, anticorps Pci, anticorps PAI3, anticorps PCI, anticorps PCI-B, anticorps PLANH3, anticorps PROCI, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, anticorps serpin family A member 5, anticorps serine (or cysteine) peptidase inhibitor, clade A, member 5, anticorps plasma serine protease inhibitor, anticorps SPIA5, anticorps SERPINA5, anticorps Serpina5, anticorps LOC480424

Sujet:

Background: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin, indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities, has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2, regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

Aliases: Acrosomal serine protease inhibitor antibody, IPSP antibody, IPSP_HUMAN antibody, PAI 3 antibody, PAI-3 antibody, PAI3 antibody, PCI antibody, PCI-B antibody, PLANH 3 antibody, PLANH3 antibody, Plasma serine protease inhibitor antibody, Plasminogen activator inhibitor 3 antibody, Plasminogen activator inhibitor III antibody, PROCI antibody, Protein C inhibitor antibody, Serpin A5 antibody, Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5 antibody, Serpin peptidase inhibitor clade A member 5 antibody, Serpina5 antibody

UniProt: P05154