POU4F1 anticorps (AA 258-419) (Biotin)

N° du produit ABIN7164064

Détail du produit anti-POU4F1 anticorps (Biotin)

Antigène: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Épitope: AA 258-419

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POU4F1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human POU domain, class 4, transcription factor 1 protein (258-419AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur POU4F1

Antigène: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Autre désignation: POU4F1 (POU4F1 Produits)

Synonymes: anticorps BRN3A, anticorps Oct-T1, anticorps RDC-1, anticorps brn-3A, anticorps POU4F1, anticorps Brn-3a, anticorps Brn-3, anticorps Brn-3.0, anticorps Brn3, anticorps Brn3.0, anticorps Brn3a, anticorps E130119J07Rik, anticorps brn3.0, anticorps brn3a, anticorps brn3a-A, anticorps oct-t1, anticorps rdc-1, anticorps POU class 4 homeobox 1, anticorps POU domain, class 4, transcription factor 1, anticorps POU class 4 homeobox 1 L homeolog, anticorps POU4F1, anticorps Pou4f1, anticorps pou4f1, anticorps Tsp_01181, anticorps pou4f1.L

Sujet:

Background: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5\'-ATGCAAAT-3\' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.

Aliases: Brain specific homeobox/POU domain protein 3A antibody, Brain-3A antibody, Brain-specific homeobox/POU domain protein 3A antibody, Brn 3.0 antibody, BRN 3A antibody, Brn-3A antibody, Brn3 antibody, BRN3A antibody, class 4 antibody, FLJ13449 antibody, Homeobox/POU domain protein RDC 1 antibody, Homeobox/POU domain protein RDC-1 antibody, Homeobox/POU domain protein RDC1 antibody, Oct T1 antibody, Oct-T1 antibody, OctT1 antibody, PO4F1_HUMAN antibody, POU class 4 homeobox 1 antibody, POU domain antibody, POU Domain Class 4 Transcription Factor 1 antibody, Pou4f1 antibody, RDC 1 antibody, RDC1 antibody, transcription factor 1 antibody

UniProt: Q01851

Pathways: Feeding Behaviour