CBFA2T3 anticorps (AA 39-159) (Biotin)

N° du produit ABIN7165195

Détail du produit anti-CBFA2T3 anticorps (Biotin)

Antigène: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Épitope: AA 39-159

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFA2T3 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protein CBFA2T3 protein (39-159AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CBFA2T3

Antigène: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Autre désignation: CBFA2T3 (CBFA2T3 Produits)

Synonymes: anticorps A630044F12Rik, anticorps AI465270, anticorps AW229127, anticorps Cbfa2t3h, anticorps ETO-2, anticorps Eto2, anticorps MTGR2, anticorps MTG16a, anticorps MTG16b, anticorps ETO2, anticorps MTG16, anticorps ZMYND4, anticorps core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human), anticorps CBFA2/RUNX1 translocation partner 3, anticorps Cbfa2t3, anticorps CBFA2T3

Sujet:

Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A, interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).

Aliases: Cbfa2t3 antibody, Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody, ETO2 antibody, hMTG16 antibody, hMTG16a antibody, hMTG16b antibody, MTG16 antibody, MTG16_HUMAN antibody, MTG8 related gene 2 antibody, MTG8 related protein MTG16a antibody, MTG8 related protein MTG16b antibody, MTG8-related protein 2 antibody, MTGR2 antibody, Myeloid translocation gene 8 and 16b antibody, Myeloid translocation gene on chromosome 16 protein antibody, Protein CBFA2T3 antibody, Zinc finger MYND domain-containing protein 4 antibody, ZMYND4 antibody

UniProt: O75081