TIMELESS anticorps (AA 1004-1131) (Biotin)

N° du produit ABIN7166188

Cet anticorps anti-TIMELESS est un anticorps Lapin Polyclonal détectant TIMELESS dans ELISA. Adapté pour Humain.

Aperçu rapide pour TIMELESS anticorps (AA 1004-1131) (Biotin) (ABIN7166188)

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMELESS est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-TIMELESS anticorps (Biotin)

Épitope: AA 1004-1131

Fonction: TIMELESS Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Protein timeless homolog protein (1004-1131AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TIMELESS

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Autre désignation: TIMELESS

Sujet:

Background: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Aliases: FLJ12640 antibody, FLJ20714 antibody, hTIM antibody, Protein timeless homolog antibody, TIM antibody, TIM_HUMAN antibody, TIM1 antibody, Timeless antibody, timeless circadian clock 1 antibody, timeless circadian clock antibody, timeless homolog antibody, TIMELESS1 antibody, Tof1 homolog antibody

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism