RSPO1 anticorps (AA 21-263)
Aperçu rapide pour RSPO1 anticorps (AA 21-263) (ABIN7166935)
Antigène
Voir toutes RSPO1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 21-263
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Réactivité croisée
- Humain
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Purification
- Antigen Affinity Purified
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Immunogène
- Recombinant Human R-spondin-1 protein (21-263AA)
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Isotype
- IgG
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Indications d'application
- Recommended dilution: IHC:1:20-1:200,
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C,-80 °C
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Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RSPO1 (R-Spondin 1 (RSPO1))
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Autre désignation
- RSPO1
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Sujet
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Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Aliases: CRISTIN3, FLJ40906, hRspo1, R spondin homolog, R spondin homolog (Xenopus laevis), R spondin1, R-spondin-1, Roof plate specific spondin, Roof plate-specific spondin-1, RP11-566C13.1, RSPO, Rspo1, RSPO1_HUMAN
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UniProt
- Q2MKA7
Antigène
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