GNB2L1 anticorps (AA 93-317)

N° du produit ABIN7167457

Détail du produit anti-GNB2L1 anticorps

Antigène: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Épitope: AA 93-317

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNB2L1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Receptor of activated protein C kinase 1 protein (93-317AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur GNB2L1

Antigène: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Autre désignation: RACK1 (GNB2L1 Produits)

Synonymes: anticorps MGC53289, anticorps GNB2L1, anticorps AL033335, anticorps GB-like, anticorps Gnb2-rs1, anticorps Rack1, anticorps p205, anticorps RACK1, anticorps H12.3, anticorps HLC-7, anticorps PIG21, anticorps rack1, anticorps wu:fb80d08, anticorps wu:fk65d12, anticorps gnb2-rs1, anticorps h12.3, anticorps hlc-7, anticorps pig21, anticorps C12-3, anticorps c12.3, anticorps guanine nucleotide binding protein, beta 2, related sequence 1, anticorps receptor for activated C kinase 1, anticorps guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, anticorps receptor for activated C kinase 1 L homeolog, anticorps Guanine nucleotide-binding protein subunit beta-2-like 1, anticorps gnb2l1, anticorps RACK1, anticorps Rack1, anticorps rack1.L, anticorps rack-1

Sujet:

Background: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).

Aliases: Cell proliferation-inducing gene 21 protein antibody, GBLP_HUMAN antibody, Gnb2-rs1 antibody, Gnb2l1 antibody, Guanine nucleotide binding protein (G protein) beta polypeptide 2 like 1 antibody, Guanine nucleotide binding protein beta polypeptide 2 like 1 antibody, Guanine nucleotide binding protein beta subunit 2 like 1 antibody, Guanine nucleotide binding protein beta subunit like protein 12.3 antibody, Guanine nucleotide binding protein subunit beta 2 like 1 antibody, Guanine nucleotide binding protein subunit beta like protein 12.3 antibody, Guanine nucleotide-binding protein subunit beta-2-like 1 antibody, Guanine nucleotide-binding protein subunit beta-like protein 12.3 antibody, H12.3 antibody, HLC-7 antibody, Human lung cancer oncogene 7 protein antibody, lung cancer oncogene 7 antibody, OTTHUMP00000223704 antibody, OTTHUMP00000223870 antibody, OTTHUMP00000223891 antibody, OTTHUMP00000223893 antibody, OTTHUMP00000223900 antibody, OTTHUMP00000223902 antibody, OTTHUMP00000223930 antibody, OTTHUMP00000223931 antibody, PIG21 antibody, Proliferation inducing gene 21 antibody, Protein homologous to chicken B complex protein guanine nucleotide binding antibody, RACK1 antibody, Receptor for activated C kinase 1 antibody, Receptor for activated C kinase antibody, Receptor of activated protein kinase C 1 antibody

UniProt: P63244

Pathways: cAMP Metabolic Process, Positive Regulation of Endopeptidase Activity