PAF1/PD2 anticorps (AA 1-300) (FITC)

N° du produit ABIN7168301

Détail du produit anti-PAF1/PD2 anticorps (FITC)

Antigène: PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAF1/PD2 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RNA polymerase II-associated factor 1 homolog protein (1-300AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PAF1/PD2

Antigène: PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))

Autre désignation: PAF1 (PAF1 Produits)

Synonymes: anticorps F23149_1, anticorps PD2, anticorps 5730511K23Rik, anticorps AA675045, anticorps f23149_1, anticorps pd2, anticorps im:6906070, anticorps paf1l, anticorps wu:fb80a09, anticorps paf1, anticorps RGD1306219, anticorps PAF1 homolog, Paf1/RNA polymerase II complex component, anticorps Paf1, RNA polymerase II complex component, anticorps PAF1 homolog, Paf1/RNA polymerase II complex component L homeolog, anticorps RNA polymerase II-associated factor 1 homolog pseudogene, anticorps RNA polymerase II-associated factor 1 homolog, anticorps paf1, RNA polymerase II associated factor, homolog (S. cerevisiae), anticorps Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae), anticorps PAF1, anticorps Paf1, anticorps paf1, anticorps paf1.L, anticorps LOC100019208, anticorps LOC100161171, anticorps LOC100639019, anticorps LOC100650306

Sujet:

Background: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \'Ser-2\'- and \'Ser-5\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \'Lys-4\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \'Lys-120\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.

Aliases: F23149 1 antibody, FLJ11123 antibody, hPAF1 antibody, PAF 1 antibody, PAF1 antibody, Paf1 RNA polymerase II associated factor homolog antibody, PAF1_HUMAN antibody, Pancreatic differentiation protein 2 antibody, PD 2 antibody, PD2 antibody, PD2 protein antibody, RNA polymerase II associated factor homolog antibody, RNA polymerase II-associated factor 1 homolog antibody

UniProt: Q8N7H5

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance