ROBO1 anticorps (AA 29-143)

N° du produit ABIN7168440

Détail du produit anti-ROBO1 anticorps

Antigène: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Épitope: AA 29-143

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROBO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Roundabout homolog 1 protein (29-143AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ROBO1

Antigène: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Autre désignation: ROBO1 (ROBO1 Produits)

Synonymes: anticorps DUTT1, anticorps SAX3, anticorps AW494633, anticorps AW742721, anticorps Gm310, anticorps ROBO1, anticorps dutt1, anticorps roundabout, anticorps sax3, anticorps MGC122264, anticorps roundabout-1, anticorps roundabout guidance receptor 1, anticorps roundabout, axon guidance receptor, homolog 1 (Drosophila), anticorps roundabout guidance receptor 1 L homeolog, anticorps ROBO1, anticorps Robo1, anticorps robo1, anticorps robo1.L

Sujet:

Background: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).

Aliases: Deleted in U twenty twenty antibody, DUTT 1 antibody, DUTT1 antibody, FLJ21882 antibody, H Robo 1 antibody, H-Robo-1 antibody, hRobo 1 antibody, Robo 1 antibody, Robo1 antibody, ROBO1_HUMAN antibody, Roundabout 1 antibody, Roundabout axon guidance receptor homolog 1 antibody, Roundabout homolog 1 antibody, Roundabout homolog1 precurser antibody, Roundabout1 antibody, SAX 3 antibody, SAX3 antibody

UniProt: Q9Y6N7

Pathways: Positive Regulation of Endopeptidase Activity