SOCS5 anticorps (AA 1-270)

N° du produit ABIN7171006

Cet anticorps anti-SOCS5 est un anticorps Lapin Polyclonal détectant SOCS5 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour SOCS5 anticorps (AA 1-270) (ABIN7171006)

Antigène: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS5 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SOCS5 anticorps

Épitope: AA 1-270

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Suppressor of cytokine signaling 5 protein (1-270AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SOCS5

Antigène: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Autre désignation: SOCS5

Sujet:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Aliases: SOCS5 antibody, CIS6 antibody, CISH5 antibody, CISH6 antibody, KIAA0671Suppressor of cytokine signaling 5 antibody, SOCS-5 antibody, Cytokine-inducible SH2 protein 6 antibody, CIS-6 antibody, Cytokine-inducible SH2-containing protein 5 antibody

UniProt: O75159

Pathways: Signalistation JAK/STAT, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process