TGFBR2 anticorps (AA 25-159)

N° du produit ABIN7171961

Détail du produit anti-TGFBR2 anticorps

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Épitope: AA 25-159

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFBR2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human TGF-beta receptor type-2 protein (25-159AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TGFBR2

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Autre désignation: TGFBR2 (TGFBR2 Produits)

Synonymes: anticorps AAT3, anticorps FAA3, anticorps LDS1B, anticorps LDS2B, anticorps MFS2, anticorps RIIC, anticorps TAAD2, anticorps TGFR-2, anticorps TGFbeta-RII, anticorps 1110020H15Rik, anticorps AU042018, anticorps DNIIR, anticorps RIIDN, anticorps TBR-II, anticorps TbetaR-II, anticorps TbetaRII, anticorps TGFBR2, anticorps TBETA-RII, anticorps TGFBRII, anticorps TGF-beta 2, anticorps Tgfbr2T, anticorps cb537, anticorps tgfbr2, anticorps wu:fj05c10, anticorps zgc:110498, anticorps transforming growth factor beta receptor 2, anticorps transforming growth factor, beta receptor II, anticorps transforming growth factor, beta receptor 2, anticorps transforming growth factor beta receptor 2b, anticorps TGFBR2, anticorps Tgfbr2, anticorps tgfbr2b

Sujet:

Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Aliases: AAT3 antibody, FAA3 antibody, LDS1B antibody, LDS2 antibody, LDS2B antibody, MFS2 antibody, RIIC antibody, TAAD2 antibody, TbetaR II antibody, TbetaR-II antibody, TGF beta receptor type 2 antibody, TGF beta receptor type II antibody, TGF beta receptor type IIB antibody, TGF beta type II receptor antibody, TGF-beta receptor type II antibody, TGF-beta receptor type-2 antibody, TGF-beta type II receptor antibody, TGF-beta-R2 antibody, TGFB R2 antibody, TGFbeta - RII antibody, TGFbeta RII antibody, Tgfbr2 antibody, TGFR-2 antibody, TGFR2_HUMAN antibody, Transforming growth factor beta receptor II antibody, Transforming growth factor beta receptor type II antibody, Transforming growth factor beta receptor type IIC antibody, Transforming growth factor, beta receptor II (70/80 kDa) antibody, transforming growth factor, beta receptor II alpha antibody, transforming growth factor, beta receptor II beta antibody, transforming growth factor, beta receptor II delta antibody, transforming growth factor, beta receptor II epsilon antibody, transforming growth factor, beta receptor II gamma antibody, Transforming growth factor-beta receptor type II antibody

UniProt: P37173