TICAM2 anticorps (AA 1-235)

N° du produit ABIN7172205

L’anticorps Lapin Polyclonal anti-TICAM2 a été validé pour ELISA et IHC. Il convient pour détecter TICAM2 dans des échantillons de Humain.

Aperçu rapide pour TICAM2 anticorps (AA 1-235) (ABIN7172205)

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TICAM2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-TICAM2 anticorps

Épitope: AA 1-235

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TICAM2

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Autre désignation: TICAM2

Sujet:

Background: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Aliases: Putative NF-kappa-B-activating protein 502 antibody, TCAM2_HUMAN antibody, TICAM-2 antibody, TICAM2 antibody, TIR containing adapter molecule 2 antibody, TIR domain containing adaptor protein antibody, TIR domain-containing adapter molecule 2 antibody, TIRAP 3 antibody, TIRAP3 antibody, TIRAP3a short form antibody, TIRP antibody, Toll-like receptor adaptor protein 3 antibody, Toll/interleukin-1 receptor domain-containing protein antibody, TRAM antibody, TRIF-related adapter molecule antibody

UniProt: Q86XR7

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades