PTPN22 anticorps (AA 1-179)

N° du produit ABIN7174103

Détail du produit anti-PTPN22 anticorps

Antigène: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Épitope: AA 1-179

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN22 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PTPN22

Antigène: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Autre désignation: PTPN22 (PTPN22 Produits)

Synonymes: anticorps 70zpep, anticorps PEP, anticorps Ptpn8, anticorps LYP, anticorps LYP1, anticorps LYP2, anticorps PTPN8, anticorps protein tyrosine phosphatase, non-receptor type 22 (lymphoid), anticorps protein tyrosine phosphatase, non-receptor type 22, anticorps Ptpn22, anticorps PTPN22

Sujet:

Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating \'Tyr-394\' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating \'Tyr-493\' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

Aliases: Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody, Lymphoid phosphatase antibody, Lymphoid specific protein tyrosine phosphatase antibody, lymphoid-specific, inducible human protein tyrosine phosphatase antibody, Lyp 1 antibody, Lyp 2 antibody, LyP antibody, Lyp1 antibody, Lyp2 antibody, LyPTP antibody, OTTHUMP00000013720 antibody, OTTHUMP00000013721 antibody, OTTHUMP00000233450 antibody, OTTHUMP00000233451 antibody, PEP antibody, PEST-domain phosphatase antibody, Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody, Protein tyrosine phosphatase non receptor type 22 antibody, Protein tyrosine phosphatase non receptor type 8 antibody, Protein tyrosine phosphatase non receptor type 8, formerly antibody, PTN22_HUMAN antibody, PTPN 22 antibody, PTPN 8 antibody, Ptpn22 antibody, PTPN8 antibody, PTPN8, formerly antibody, Tyrosine-protein phosphatase non-receptor type 22 antibody

UniProt: Q9Y2R2