USP8 anticorps (AA 1-270)

N° du produit ABIN7174360

Cet anticorps anti-USP8 est un anticorps Lapin Polyclonal détectant USP8 dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour USP8 anticorps (AA 1-270) (ABIN7174360)

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-USP8 anticorps

Épitope: AA 1-270

Fonction: USP8 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP8

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Autre désignation: USP8

Sujet:

Background: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both \\\'Lys-48\\\' an \\\'Lys-63\\\'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Aliases: Deubiquitinating enzyme 8 antibody, FLJ34456 antibody, hUBPy antibody, HumORF8 antibody, KIAA0055 antibody, MGC129718 antibody, SPG59 antibody, Ubiquitin carboxyl-terminal hydrolase 8 antibody, Ubiquitin isopeptidase Y antibody, ubiquitin specific peptidase 8 antibody, Ubiquitin thioesterase 8 antibody, Ubiquitin-specific-processing protease 8 antibody, UBP8_HUMAN antibody, UBPY antibody, Usp8 antibody

UniProt: P40818