OGT anticorps (AA 606-1022)

N° du produit ABIN7174654

Détail du produit anti-OGT anticorps

Antigène: OGT (O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT))

Épitope: AA 606-1022

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OGT est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit protein (606-1022AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur OGT

Antigène: OGT (O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT))

Autre désignation: OGT (OGT Produits)

Synonymes: anticorps BcDNA:GH04245, anticorps CG10392, anticorps Dmel\\CG10392, anticorps OGT, anticorps Ogt, anticorps P1201, anticorps SXC, anticorps Sxc, anticorps l(2)02637, anticorps l(2)NC130, anticorps sxc/Ogt, anticorps fm81g08, anticorps ogt, anticorps wu:fc12b01, anticorps wu:fm81g08, anticorps HRNT1, anticorps O-GLCNAC, anticorps 1110038P24Rik, anticorps 4831420N21Rik, anticorps AI115525, anticorps Ogtl, anticorps O-linked N-acetylglucosamine (GlcNAc) transferase L homeolog, anticorps super sex combs, anticorps O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1, anticorps O-linked N-acetylglucosamine (GlcNAc) transferase, anticorps O-linked GlcNAc transferase, anticorps o-linked GlcNAc transferase, anticorps O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), anticorps ogt.L, anticorps sxc, anticorps ogt.1, anticorps OGT, anticorps ogt, anticorps GL50803_12081, anticorps GL50803_41701, anticorps THAPSDRAFT_264441, anticorps spyA, anticorps Ogt

Sujet:

Background: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the \\\'Thr-308\\\' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of \\\'Ser-112\\\' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of \\\'Ser-75\\\' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2.

Aliases: FLJ23071 antibody, GlcNAc transferase antibody, HRNT1 antibody, MGC22921 antibody, O GlcNAc antibody, O GlcNAc transferase p110 subunit antibody, O GlcNAc transferase subunit p110 antibody, O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase) antibody, O linked N acetylglucosamine (GlcNAc) transferase antibody, O linked N acetylglucosamine transferase 110 kDa subunit antibody, O-GlcNAc transferase subunit p110 antibody, O-linked N-acetylglucosamine transferase 110 kDa subunit antibody, ogt antibody, OGT1_HUMAN antibody, UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit antibody, UDP N acetylglucosamine peptide N acetylglucosaminyltransferase GlcNAc transferase antibody, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit antibody, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase antibody, Uridinediphospho N acetylglucosamine:polypeptide beta N acetylglucosaminyl transferase antibody

UniProt: O15294

Pathways: Regulation of Carbohydrate Metabolic Process