MAP2K4 anticorps (AA 2-397)

N° du produit ABIN7177157

Détail du produit anti-MAP2K4 anticorps

Antigène: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Épitope: AA 2-397

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2K4 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 protein (2-397AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAP2K4

Antigène: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Autre désignation: Map2k4 (MAP2K4 Produits)

Synonymes: anticorps JNKK, anticorps JNKK1, anticorps MAPKK4, anticorps MEK4, anticorps MKK4, anticorps PRKMK4, anticorps SAPKK-1, anticorps SAPKK1, anticorps SEK1, anticorps SERK1, anticorps SKK1, anticorps Sek1, anticorps Serk1, anticorps MKK4A-l, anticorps map2k4, anticorps zgc:136500, anticorps jnkk, anticorps mek4, anticorps mkk4, anticorps sek1, anticorps jnkk1, anticorps serk1, anticorps xmek2, anticorps mapkk4, anticorps prkmk4, anticorps 142758_at, anticorps CG9738, anticorps CT27508, anticorps D-MKK4, anticorps DMKK4, anticorps Dmel\\CG9738, anticorps JNKK2, anticorps Mpk4, anticorps SEK1/MKK4, anticorps dMKK4, anticorps dMkk4, anticorps hep, anticorps ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, anticorps ATMEK4, anticorps ATMKK4, anticorps F19C24.26, anticorps F19C24_26, anticorps MAP KINASE KINASE 4, anticorps mitogen-activated protein kinase kinase 4, anticorps MKK4B, anticorps zgc:194486, anticorps mitogen-activated protein kinase kinase 4, anticorps mitogen-activated protein kinase kinase 4a, anticorps MAP kinase kinase 4, anticorps mitogen activated protein kinase kinase 4, anticorps mitogen-activated protein kinase kinase 4b, anticorps MAP2K4, anticorps Map2k4, anticorps map2k4a, anticorps map2k4, anticorps Mkk4, anticorps MKK4, anticorps map2k4b

Sujet:

Background: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Aliases: Map2k4 antibody, Jnkk1 antibody, Mek4 antibody, Mkk4 antibody, Prkmk4 antibody, Sek1 antibody, Serk1 antibody, Skk1 antibody, Dual specificity mitogen-activated protein kinase kinase 4 antibody, MAP kinase kinase 4 antibody, MAPKK 4 antibody, EC 2.7.12.2 antibody, C-JUN N-terminal kinase kinase 1 antibody, JNK kinase 1 antibody, JNKK 1 antibody, JNK-activating kinase 1 antibody, MAPK/ERK kinase 4 antibody, MEK 4 antibody, SAPK/ERK kinase 1 antibody, SEK1 antibody

UniProt: P47809

Pathways: Signalisation MAPK, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling