Ephrin A1 anticorps (AA 18-182)

N° du produit ABIN7178841

Détail du produit anti-Ephrin A1 anticorps

Antigène: Ephrin A1 (EFNA1)

Épitope: AA 18-182

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A1 est non-conjugé

Application: ELISA

Réactivité croisée: Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Rat Ephrin-A1 protein (18-182AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Ephrin A1

Antigène: Ephrin A1 (EFNA1)

Autre désignation: Efna1 (EFNA1 Produits)

Synonymes: anticorps Xefrin-A1, anticorps b61, anticorps ecklg, anticorps efl1, anticorps efna1, anticorps efna1a, anticorps elfa-a, anticorps epha1, anticorps eplg1, anticorps lerk1, anticorps tnfaip4, anticorps xelf-a', anticorps xelfa, anticorps AI325262, anticorps B61, anticorps Efl1, anticorps Epl1, anticorps Eplg1, anticorps Lerk1, anticorps ECKLG, anticorps EFL1, anticorps EPLG1, anticorps LERK-1, anticorps LERK1, anticorps TNFAIP4, anticorps efna1b, anticorps MGC130661, anticorps ephrin-A1 S homeolog, anticorps ephrin-A1, anticorps ephrin A1, anticorps ephrin-A1b, anticorps ephrin-A1 L homeolog, anticorps efna1.S, anticorps efna1, anticorps EFNA1, anticorps efna1b, anticorps Efna1, anticorps efna1.L

Sujet:

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis By similarity.

Aliases: Efna1 antibody, Epgl1 antibody, Lerk1 antibody, Ephrin-A1 antibody, EPH-related receptor tyrosine kinase ligand 1 antibody, LERK-1 antibody, Immediate early response protein B61) [Cleaved into: Ephrin-A1 antibody, secreted form] antibody

UniProt: P97553

Pathways: Signalisation RTK