Cyclin C anticorps (Ser275)

N° du produit ABIN7179998

Cet anticorps Lapin Polyclonal détecte spécifiquement Cyclin C dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Cyclin C anticorps (Ser275) (ABIN7179998)

Antigène: Cyclin C (CCNC)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin C est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Cyclin C anticorps

Épitope: Ser275

Fonction: CCNC (Ab-275) Antibody

Réactivité croisée: Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N).

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cyclin C

Antigène: Cyclin C (CCNC)

Autre désignation: CCNC

Sujet:

Background: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Lew D.J., Cell 66:1197-1206(1991).
Li H., Genomics 32:253-259(1996).
Mungall A.J., Nature 425:805-811(2003).

Aliases: ccnc antibody, CCNC_HUMAN antibody, CycC antibody, Cyclin C antibody, Cyclin-C antibody, hSRB11 antibody, OTTHUMP00000016897 antibody, SRB11 homolog antibody

UniProt: P24863

Pathways: Cycle Cellulaire, Regulation of Lipid Metabolism by PPARalpha