JAK3 anticorps (Tyr785)

N° du produit ABIN7180037

Cet anticorps Lapin Polyclonal détecte spécifiquement JAK3 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour JAK3 anticorps (Tyr785) (ABIN7180037)

Antigène: JAK3 (Janus Kinase 3 (JAK3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAK3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-JAK3 anticorps

Épitope: Tyr785

Fonction: JAK3 (Ab-785) Antibody

Réactivité croisée: Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human JAK3 around the phosphorylation site of tyrosine 785 (S-D-Y(p)-E-L).

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur JAK3

Antigène: JAK3 (Janus Kinase 3 (JAK3))

Autre désignation: JAK3

Sujet:

Background: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 Molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Kawamura M., Proc. Natl. Acad. Sci. U.S.A. 91:6374-6378(1994).
Lai K.S., J. Biol. Chem. 270:25028-25036(1995).
Grimwood J., Nature 428:529-535(2004).

Aliases: EC 2.7.10.2 antibody, JAK 3 antibody, JAK L antibody, JAK-3 antibody, Jak3 antibody, JAK3 HUMAN antibody, JAK3_HUMAN antibody, JAKL antibody, Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody, Janus kinase 3 antibody, Janus Kinase3 antibody, L JAK antibody, L-JAK antibody, Leukocyte janus kinase antibody, LJAK antibody, Protein tyrosine kinase leukocyte antibody, Tyrosine protein kinase JAK3 antibody, Tyrosine-protein kinase JAK3 antibody

UniProt: P52333

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response