GRK2 anticorps (N-Term)

N° du produit ABIN7184410

Cet anticorps anti-GRK2 est un anticorps Lapin Polyclonal détectant GRK2 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour GRK2 anticorps (N-Term) (ABIN7184410)

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-GRK2 anticorps

Épitope: N-Term

Fonction: ADRBK1 (Ab-86) Antibody

Réactivité croisée: Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from N-terminal of Human ADRBK1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur GRK2

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Autre désignation: ADRBK1

Sujet:

Background: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Benovic J.L., FEBS Lett. 283:122-126(1991).
Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).
Penn R.B., J. Biol. Chem. 269:14924-14930(1994).

Aliases: ADRBK1 antibody, Adrenergic beta receptor kinase 1 antibody, ARBK1_HUMAN antibody, BARK antibody, BARK1 antibody, Beta adrenergic receptor kinase 1 antibody, Beta ARK 1 antibody, Beta ARK1 antibody, Beta-adrenergic receptor kinase 1 antibody, Beta-ARK-1 antibody, FLJ16718 antibody, G protein coupled receptor kinase 2 antibody, G-protein coupled receptor kinase 2 antibody, GRK2 antibody

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling