SUMO1 anticorps (N-Term)

N° du produit ABIN7184508

L’anticorps Lapin Polyclonal anti-SUMO1 a été validé pour WB, IF, IHC et ELISA. Il convient pour détecter SUMO1 dans des échantillons de Humain.

Aperçu rapide pour SUMO1 anticorps (N-Term) (ABIN7184508)

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUMO1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Détail du produit anti-SUMO1 anticorps

Épitope: N-Term

Fonction: SUMO1 Antibody

Réactivité croisée: Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from N-terminal of Human SUMO-1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SUMO1

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Autre désignation: SUMO1

Sujet:

Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.

Margarita Vigodner, Am J Physiol Endocrinol Metab, May 2006, 290: E1022 - E1033.
Adrian Minty, J. Biol. Chem., Nov 2000, 275: 36316.
Deborah A. Sampson, J. Biol. Chem., Jun 2001, 276: 21664 - 21669.
Hidehisa Takahashi, J. Biol. Chem., Feb 2005, 280: 56

Aliases: DAP1 antibody, GAP modifying protein 1 antibody, GAP-modifying protein 1 antibody, GMP 1 antibody, GMP1 antibody, OFC10 antibody, PIC 1 antibody, PIC1 antibody, SENP2 antibody, Sentrin 1 antibody, Sentrin antibody, Small ubiquitin related modifier 1 antibody, Small ubiquitin-like modifier 1 antibody, Small ubiquitin-related modifier 1 antibody, SMT3 antibody, SMT3 homolog 3 antibody, SMT3 suppressor of mif two 3 homolog 1 antibody, SMT3, yeast, homolog 3 antibody, Smt3C antibody, SMT3H3 antibody, SUMO-1 antibody, SUMO1 antibody, SUMO1_HUMAN antibody, Ubiquitin homology domain protein PIC1 antibody, Ubiquitin Like 1 antibody, Ubiquitin like protein SMT3C antibody, Ubiquitin like protein UBL1 antibody, Ubiquitin-homology domain protein PIC1 antibody, Ubiquitin-like protein SMT3C antibody, Ubiquitin-like protein UBL1 antibody, UBL 1 antibody, UBL1 antibody

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway