CABLES2 anticorps

N° du produit ABIN7190032

Détail du produit anti-CABLES2 anticorps

Antigène: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CABLES2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human CABLES2

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:1000-1:2000, IHC:1:25-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CABLES2

Antigène: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Autre désignation: CABLES2 (CABLES2 Produits)

Synonymes: anticorps cables2, anticorps CABLES2, anticorps C20orf150, anticorps dJ908M14.2, anticorps ik3-2, anticorps Cdk5 and Abl enzyme substrate 2, anticorps CDK5 and Abl enzyme substrate 2, anticorps CABLES2, anticorps cables2, anticorps Cables2

Sujet:

Background: Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78 % sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Aliases: CABLES2 antibody, C20orf150 antibody, CDK5 and ABL1 enzyme substrate 2 antibody, Interactor with CDK3 2 antibody, Ik3-2 antibody

UniProt: Q9BTV7