IGF1R anticorps (pTyr1161)

N° du produit ABIN7213316

Cet anticorps anti-IGF1R Polyclonal Lapin (ABIN7213316) détecte spécifiquement IGF1R dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour IGF1R anticorps (pTyr1161) (ABIN7213316)

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-IGF1R anticorps

Épitope: pTyr1161

Fonction: Rabbit Anti-IGF-IR (phospho Tyr1161) Polyclonal Antibody

Specificité: Phospho-IGF-IR (Y1161) Polyclonal Antibody detects endogenous levels of IGF-IR protein only when phosphorylated at Y1161.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human IGF-IR Phospho-Tyr1161

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: IGF-IR

Sujet: IGF1R, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, CD antigen CD221, INSR, Insulin receptor, IR, CD antigen CD220Insulin like growth factor 1 receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for IGF1R.

Poids moléculaire: pro:155kD,recetor beta:95kD

ID gène: 3480

UniProt: P08069, P06213

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy