Leptin Receptor anticorps (pTyr1141)

N° du produit ABIN7213352

L’anticorps Lapin Polyclonal anti-Leptin Receptor a été validé pour WB et ELISA. Il convient pour détecter Leptin Receptor dans des échantillons de Humain et Souris.

Aperçu rapide pour Leptin Receptor anticorps (pTyr1141) (ABIN7213352)

Antigène: Leptin Receptor (LEPR)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Leptin Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Leptin Receptor anticorps

Épitope: pTyr1141

Fonction: Ob-R (phospho Tyr1141) Polyclonal Antibody

Specificité: Phospho-Ob-R (Y1141) Polyclonal Antibody detects endogenous levels of Ob-R protein only when phosphorylated at Y1141.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from human Ob-R Phospho-Tyr1141

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur Leptin Receptor

Antigène: Leptin Receptor (LEPR)

Autre désignation: Ob-R

Sujet: Rabbit Anti-Ob-R (phospho Tyr1141) Polyclonal Antibody,LEPR, DB, OBR, Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD antigen CD295,Leptin receptor encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. Leptin receptor is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in LEPR have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for LEPR. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).,Leptin receptor

Poids moléculaire: observerd band 132kDa

ID gène: 3953

UniProt: P48357

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour