Caspase 8 anticorps

N° du produit ABIN7266121

Cet anticorps Lapin Monoclonal détecte spécifiquement Caspase 8 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour Caspase 8 anticorps (ABIN7266121)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Caspase 8 anticorps

Fonction: Caspase-8 Rabbit mAb

Réactivité croisée: Humain

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human Caspase-8.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: CASP8

Sujet: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008],ALPS2B,CAP4,Casp-8,FLICE,MACH,MCH5,Caspase 8,CASP8,Caspase-8,caspase-8,Apoptosis,Apoptosis_Caspases,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cancer,Cell Biology & Developmental Biology,Death Receptor Signaling Pathway,Endocrine & Metabolism,ErbB-HER Signaling Pathway,Immunology & Inflammation,Invasion and Metastasis,Neurodegenerative Diseases,Neuroscience,Signal Transduction,Toll-like Receptor Signaling Pathway,Ubiquitin,CASP8

Poids moléculaire: 55kDa

ID gène: 841

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades