COL4a3 anticorps (C-Term)

N° du produit ABIN7266460

Détail du produit anti-COL4a3 anticorps

Antigène: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COL4a3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: COL4A3 Rabbit pAb

Séquence: SPGSCLEEFR ASPFLECHGR GTCNYYSNSY SFWLASLNPE RMFRKPIPST VKAGELEKII SRCQVCMKKR H

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human COL4A3 (NP_000082.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur COL4a3

Antigène: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Autre désignation: COL4A3 (COL4A3 Produits)

Synonymes: anticorps zTumstatin, anticorps [a]3(IV), anticorps alpha3(IV), anticorps collagen type IV alpha 3 chain, anticorps collagen, type IV, alpha 3, anticorps COL4A3, anticorps col4a3, anticorps Col4a3

Sujet: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.,COL4A3,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Extracellular Matrix,Collagen,Immunology & Inflammation,Cardiovascular,Angiogenesis,Angiogenic inhibitory factors,COL4A3

Poids moléculaire: 135kDa/142kDa/158kDa/161kDa

ID gène: 1285

UniProt: Q01955

Pathways: Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity