FEM1A anticorps (AA 100-300)

N° du produit ABIN7267165

Détail du produit anti-FEM1A anticorps

Antigène: FEM1A (Fem-1 Homolog A (FEM1A))

Épitope: AA 100-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FEM1A est non-conjugé

Application: Western Blotting (WB)

Fonction: FEM1A Rabbit pAb

Séquence: RSLLRRGASV NRTTRTNSTP LRAACFDGHL EVVRYLVGEH QADLEVANRH GHTCLMISCY KGHREIARYL LEQGAQVNRR SAKGNTALHD CAESGSLEIL QLLLGCKARM ERDGYGMTPL LAASVTGHTN IVEYLIQEQP GQEQVAGGEA QPGLPQEDPS TSQGCAQPQG APCCSSSPEE PLNGESYESC CPTSREAAVE A

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FEM1A

Antigène: FEM1A (Fem-1 Homolog A (FEM1A))

Autre désignation: FEM1A (FEM1A Produits)

Synonymes: anticorps EPRAP, anticorps fi20c04, anticorps wu:fi20c04, anticorps zgc:63483, anticorps AW611390, anticorps Fem1aa, anticorps fem-1 homolog A, anticorps fem-1 homolog a (C. elegans), anticorps feminization 1 homolog a (C. elegans), anticorps FEM1A, anticorps Fem1a, anticorps fem1a

Sujet: Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity.,FEM1A,EPRAP,Cell Biology & Developmental Biology,Apoptosis,Caspases,FEM1A

Poids moléculaire: 73kDa

ID gène: 55527

UniProt: Q9BSK4