FGD5 anticorps (AA 1000-1200)

N° du produit ABIN7267286

Détail du produit anti-FGD5 anticorps

Antigène: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Épitope: AA 1000-1200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGD5 est non-conjugé

Application: Western Blotting (WB)

Fonction: FGD5 Rabbit pAb

Séquence: YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY G

Réactivité croisée: Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_689749.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FGD5

Antigène: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Autre désignation: FGD5 (FGD5 Produits)

Synonymes: anticorps ZFYVE23, anticorps C330025N11Rik, anticorps mFLJ00274, anticorps FYVE, RhoGEF and PH domain containing 5, anticorps Fgd5, anticorps FGD5

Sujet: FGD5 (or ZFYVE23) is an endothelial specific gene, plays a crucial role in vascular pruning. Deficient expression of FGD5 markedly inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. FGD5-deficient endothelial cells fail to migrate. Moreover, the cells are susceptible to proapoptotic stimuli associated with VEGF-stimulated activation of Akt. FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of CDC42.,FGD5,ZFYVE23,FYVE,Signal Transduction,G protein signaling,Signal Transduction,FGD5

Poids moléculaire: 61kDa/159kDa

ID gène: 152273

UniProt: Q6ZNL6