Band 3/AE1 anticorps (AA 1-353)

N° du produit ABIN7270459

Détail du produit anti-Band 3/AE1 anticorps

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Épitope: AA 1-353

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Band 3/AE1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: SLC4A1 Rabbit pAb

Séquence: MEELQDDYED MMEENLEQEE YEDPDIPESQ MEEPAAHDTE ATATDYHTTS HPGTHKVYVE LQELVMDEKN QELRWMEAAR WVQLEENLGE NGAWGRPHLS HLTFWSLLEL RRVFTKGTVL LDLQETSLAG VANQLLDRFI FEDQIRPQDR EELLRALLLK HSHAGELEAL GGVKPAVLTR SGDPSQPLLP QHSSLETQLF CEQGDGGTEG HSPSGILEKI PPDSEATLVL VGRADFLEQP VLGFVRLQEA AELEAVELPV PIRFLFVLLG PEAPHIDYTQ LGRAAATLMS ERVFRIDAYM AQSRGELLHS LEGFLDCSLV LPPTDAPSEQ ALLSLVPVQR ELLRRRYQSS PAK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human SLC4A1 (NP_000333.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Band 3/AE1

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Autre désignation: SLC4A1 (SLC4A1 Produits)

Synonymes: anticorps AE1, anticorps BND3, anticorps CD233, anticorps DI, anticorps EMPB3, anticorps EPB3, anticorps FR, anticorps RTA1A, anticorps SW, anticorps WD, anticorps WD1, anticorps WR, anticorps Ae1, anticorps Empb3, anticorps l11Jus51, anticorps ae1, anticorps band3, anticorps MGC152771, anticorps zgc:111889, anticorps zgc:152771, anticorps si:dz180g5.1, anticorps LOC100136769, anticorps slc4a1, anticorps wd1, anticorps bnd3, anticorps epb3, anticorps cd233, anticorps empb3, anticorps rta1a, anticorps MGC80391, anticorps SLC4A1, anticorps BB3, anticorps EAT, anticorps solute carrier family 4 member 1 (Diego blood group), anticorps solute carrier family 4 (anion exchanger), member 1, anticorps solute carrier family 4 (anion exchanger), member 1a (Diego blood group), anticorps Band 3, anticorps erythrocyte membrane protein band 4.1 like 3, anticorps solute carrier family 4 member 1 (Diego blood group) L homeolog, anticorps solute carrier family 4 member 1, anticorps SLC4A1, anticorps Slc4a1, anticorps slc4a1a, anticorps LOC100136769, anticorps EPB41L3, anticorps slc4a1.L, anticorps slc4a1

Sujet: The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40 kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system.One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.,DI,FR,SW,WD,WR,AE1,CHC,SAO,WD1,BND3,EPB3,SPH4,CD233,EMPB3,RTA1A,SLC4A1,Immunology & Inflammation,CD markers,Cardiovascular,Blood,Blood Cell Antigens,SLC4A1

ID gène: 6521

UniProt: P02730