ZCCHC3 anticorps (AA 215-335)

N° du produit ABIN7271543

Détail du produit anti-ZCCHC3 anticorps

Antigène: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Épitope: AA 215-335

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZCCHC3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: ZCCHC3 Rabbit pAb

Séquence: SFRSAEKLAL FLRVYEEKRE QEDCWENFVV LGRSKSSLKT LFILFRNETV DVEDIVTWLK RHCDVLAVPV KVTDRFGIWT GEYKCEIELR QGEGGVRHLP GAFFLGAERG YSWYKGQPKT C

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 215-335 of human ZCCHC3 (NP_149080.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ZCCHC3

Antigène: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Autre désignation: ZCCHC3 (ZCCHC3 Produits)

Synonymes: anticorps C20orf99, anticorps 2810406K24Rik, anticorps zinc finger CCHC-type containing 3, anticorps zinc finger, CCHC domain containing 3, anticorps ZCCHC3, anticorps Zcchc3

Sujet: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus. Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation. Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA, enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5.,ZCCHC3,C20orf99,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,ZCCHC3

Poids moléculaire: 43kDa

ID gène: 85364

UniProt: Q9NUD5