Bcl-2 anticorps (AA 41-54)
Aperçu rapide pour Bcl-2 anticorps (AA 41-54) (ABIN7272015)
Antigène
Voir toutes Bcl-2 (BCL2) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Classe de qualité
Clone
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Épitope
- AA 41-54
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Fonction
- BCL-2 Unconjugated Antibody
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Attributs du produit
- The clone 100, a mouse monoclonal antibody, recognizes a 239 amino acid ~25 kDa human apoptosis regulator oncoprotein known as Bcl-2. It is an intracellular, integral membrane protein containing up to 4 Bcl-2 homology (BH) motifs which are found primarily in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membrane. Bcl-2 is a conserved anti-apoptotic protein and plays important roles in the management of normal immunity. Nonrandom translocations with breakpoint at band q21 on chromosome 18 may cause bcl-2 gene deregulation and contribute to neoplastic transformation in human lymphomas.
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Purification
- Purified
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Pureté
- >95 %
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Immunogène
- Human BCL-2 synthetic peptide aa. 41-54
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Isotype
- IgG1, kappa
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Autre désignation
- BCL-2
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ID gène
- 596
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UniProt
- P10415
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Pathways
- Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Antigène
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