Recombinant TGFB1 anticorps (AA 325-375)

N° du produit ABIN7449529

Cet anticorps Lapin Monoclonal détecte spécifiquement TGFB1 dans WB, IHC, ICC et FACS. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Recombinant TGFB1 anticorps (AA 325-375) (ABIN7449529)

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TGFB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: BLR195J

Détail du produit anti-TGFB1 anticorps

Épitope: AA 325-375

Fonction: Rabbit anti-TGF-beta 1 Recombinant Monoclonal Antibody [BLR195J]

Immunogène: between AA 325 and 375

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TGFB1

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Autre désignation: TGF-beta 1

Sujet: Background: The Transforming growth factor beta-1 preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature TGF-beta 1 peptide. TGF-beta 1 bound to LAP is inactive, while the active form consists solely of the mature peptide homodimer. The mature TGF-beta 1 peptide may also form heterodimers with other TGFB family members. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. TGF-beta 1 regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells. [taken from NCBI Entrez Gene (Gene ID: 7040)].

ID gène: 7040

NCBI Accession: NP_000651

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints