MDC1 anticorps (AA 475-525)

N° du produit ABIN7449894

Cet anticorps anti-MDC1 est un anticorps Lapin Polyclonal détectant MDC1 dans WB et IP. Adapté pour Humain.

Aperçu rapide pour MDC1 anticorps (AA 475-525) (ABIN7449894)

Antigène: MDC1 (Mdc1 (MDC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDC1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-MDC1 anticorps

Épitope: AA 475-525

Fonction: Rabbit anti-MDC1 Antibody, Affinity Purified

Homologie: Monkey,Chimpanzee

Purification: Affinity Purified

Immunogène: between AA 475 and 525

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MDC1

Antigène: MDC1 (Mdc1 (MDC1))

Autre désignation: MDC1

Sujet: Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) Q5PSV9].

ID gène: 9656

NCBI Accession: NP_055456

UniProt: Q14676