MDC1 anticorps (AA 900-950)

N° du produit ABIN7451086

Cet anticorps Lapin Polyclonal détecte spécifiquement MDC1 dans IP. Il présente une réactivité envers Souris.

Aperçu rapide pour MDC1 anticorps (AA 900-950) (ABIN7451086)

Antigène: MDC1 (Mdc1 (MDC1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDC1 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-MDC1 anticorps

Épitope: AA 900-950

Fonction: Rabbit anti-Mdc1/Nfbd1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 900 and 950

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451086 has not performed satisfactorily when used for WB of Mdc1/Nfbd1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Mdc1/Nfbd1.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MDC1

Antigène: MDC1 (Mdc1 (MDC1))

Autre désignation: Mdc1/Nfbd1

Sujet: Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) Q5PSV9].

ID gène: 240087

NCBI Accession: NP_001010833

UniProt: Q5PSV9