CSK anticorps (AA 375-425)

N° du produit ABIN7451223

Cet anticorps anti-CSK est un anticorps Lapin Polyclonal détectant CSK dans IP. Adapté pour Humain.

Aperçu rapide pour CSK anticorps (AA 375-425) (ABIN7451223)

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSK est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-CSK anticorps

Épitope: AA 375-425

Fonction: Rabbit anti-CSK Antibody, Affinity Purified

Homologie: Mouse,Rat,Chicken,Bovine

Purification: Affinity Purified

Immunogène: Between AA 375 and 425

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-CSK antibody ABIN7450141.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CSK

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Autre désignation: CSK

Sujet: Background: C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) P41240].

ID gène: 1445

NCBI Accession: NP_004374

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events