CAND1 anticorps (AA 1180-1230)
Aperçu rapide pour CAND1 anticorps (AA 1180-1230) (ABIN7453479)
Antigène
Voir toutes CAND1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 1180-1230
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Fonction
- Rabbit anti-CAND1 Antibody, Affinity Purified
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Homologie
- Rat,Bovine,Orangutan
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Purification
- Affinity Purified
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Immunogène
- between AA 1180 and 1230
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Isotype
- IgG
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Indications d'application
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Restrictions
- For Research Use only
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Concentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C
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Date de péremption
- 12 months
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- CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))
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Autre désignation
- CAND1
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Sujet
- Background: Cullin-associated NEDD8-dissociated protein 1 (CAND1) is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site and disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins. CAND1 also binds TATA binding protein and enhances transcription from various promoters [taken from the Universal Protein Resource (UniProt) Q86VP6].
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ID gène
- 55832
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NCBI Accession
- NP_060918
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UniProt
- Q86VP6
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Pathways
- Regulation of Actin Filament Polymerization
Antigène
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