NCOR2 anticorps (AA 994-1005)

N° du produit ABIN7464419

Cet anticorps anti-NCOR2 est un anticorps Souris Monoclonal détectant NCOR2 dans WB, IP, IHC (fro) et ChIP. Adapté pour Humain.

Aperçu rapide pour NCOR2 anticorps (AA 994-1005) (ABIN7464419)

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NCOR2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Chromatin Immunoprecipitation (ChIP)

Classe de qualité: KO Validated

Clone: 1212

Détail du produit anti-NCOR2 anticorps

Épitope: AA 994-1005

Réactivité croisée: Humain, Singe

Purification: Protein G purified

Immunogène: A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH.

Isotype: IgG1

Information d'application

Indications d'application: For ChIP: Use 3 μL for 10^6 cells. For IHC-Fr: Use at a dilution of 1:50. Immunohistochemical staining of SMRT in HeLa cells with this antibody results in nuclear staining. For WB: Use at a dilution of 1:250. Detects a band of approximately 220-250 kDa (predicted molecular weight: 274 kDa). Optimal dilutions/concentration should be determined by the researcher.

Commentaires:

Positive Control: HBL100

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur NCOR2

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Autre désignation: nuclear receptor corepressor 2

Sujet: Nuclear receptor corepressor 2 , CTG26 , N-CoR2 , SMAP270 , SMRT , SMRTE , SMRTE-tau , TNRC14 , TRAC , TRAC-1 , TRAC1,This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Poids moléculaire: 274 kDa

ID gène: 9612

UniProt: Q9Y618

Pathways: Signalisation Notch, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha