ID4 anticorps (AA 61-160)

N° du produit ABIN719696

Détail du produit anti-ID4 anticorps

Antigène: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Épitope: AA 61-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ID4 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ID4

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ID4

Antigène: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Autre désignation: ID4 (ID4 Produits)

Synonymes: anticorps Idb4, anticorps bHLHb27, anticorps cb547, anticorps fb77d04, anticorps sb:cb547, anticorps wu:fb77d04, anticorps zgc:123214, anticorps bhlhb27, anticorps id4, anticorps id4a, anticorps idb4, anticorps IDB4, anticorps inhibitor of DNA binding 4, anticorps inhibitor of DNA binding 4, HLH protein, anticorps inhibitor of DNA binding 4, HLH protein S homeolog, anticorps Id4, anticorps id4, anticorps id4.S, anticorps ID4

Sujet:

Synonyms: bHLHb27, Class B basic helix-loop-helix protein 27, DNA binding protein inhibitor ID 4, DNA binding protein inhibitor ID4, DNA-binding protein inhibitor ID-4, ID 4, Id4, ID4_HUMAN, IDB4, Inhibitor of DNA binding 4, Inhibitor of DNA binding 4 dominant negative helix loop helix protein.

Background: Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

ID gène: 3400